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GPS1 / CSN1
G protein pathway suppressor 1
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
| Gene Name: | G protein pathway suppressor 1 |
| Synonyms: | GPS1, COPS1, CSN1, G protein pathway suppressor 1, GPS-1, SGN1, Signalosome subunit 1, Protein MFH |
| Target Sequences: | NM_004127 NP_004118.3 Q13098 |
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GPS1 / CSN1 Goat anti-Human Polyclonal (aa516-527) Antibody
Chicken, Bovine, Rat, Hamster, Horse, Bat, Mouse, Dog, Human, Monkey
IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
GPS1 / CSN1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$351
GPS1 / CSN1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
GPS1 / CSN1 Rabbit anti-Human Polyclonal (aa222-491) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
GPS1 / CSN1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
GPS1 / CSN1 Rabbit anti-Human Polyclonal (aa222-491) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
GPS1 / CSN1 Rabbit anti-Human Polyclonal (aa400-C-term) Antibody
Human
IHC, WB
Unconjugated
10 µl/$295; 100 µl/$514
GPS1 / CSN1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P
Unconjugated
100 µg/$357
GPS1 / CSN1 Rabbit anti-Human Polyclonal (390-470 aa) Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
GPS1 / CSN1 Rabbit anti-Human Polyclonal (390-470 aa) Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
GPS1 / CSN1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50 µl/$334; 100 µl/$397
GPS1 / CSN1 Rabbit anti-Human Polyclonal (pSer454) Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
100 µg/$357
GPS1 / CSN1 Rabbit anti-Human Polyclonal (pSer454) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
GPS1 / CSN1 Rabbit anti-Human Polyclonal (aa141-170) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
GPS1 / CSN1 Rabbit anti-Mouse Polyclonal (aa141-170) (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
200 µl/$952
GPS1 / CSN1 Rabbit anti-Mouse Polyclonal (aa141-170) (FITC) Antibody
Mouse
ELISA, WB
FITC Conjugated
200 µl/$952
GPS1 / CSN1 Rabbit anti-Mouse Polyclonal (aa141-170) (APC) Antibody
Mouse
ELISA, WB
APC Conjugated
200 µl/$952
GPS1 / CSN1 Rabbit anti-Mouse Polyclonal (aa141-170) (Azide-free) (HRP) Antibody
Mouse
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
GPS1 / CSN1 Rabbit anti-Mouse Polyclonal (aa141-170) (PE) Antibody
Mouse
ELISA, WB
PE Conjugated
200 µl/$952
GPS1 / CSN1 Rabbit anti-Human Polyclonal (aa400-C-term) Antibody
Human
IHC
Unconjugated
2.5 µg/$295; 100 µl/$532
GPS1 / CSN1 Mouse anti-Human Monoclonal (1E8) Antibody
Human
ELISA
Unconjugated
100 µg/$423
GPS1 / CSN1 Rabbit anti-Human Polyclonal (aa141-170) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$393
GPS1 / CSN1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
GPS1 / CSN1 Rabbit anti-Human Polyclonal (aa82-131) Antibody
Human
WB
Unconjugated
100 µl/$424
GPS1 / CSN1 Rabbit anti-Human Polyclonal (aa16-185) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
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