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Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer.
Gene Name: | G protein-coupled receptor 68 |
Family/Subfamily: | GPCR , Lysophospholipid/Lysosphingolipid |
Synonyms: | GPR68, Brgrb, G protein-coupled receptor 68, G-protein coupled receptor 68, OGR1, Brgr1, GPR12A, OGR-1 |
Target Sequences: | NM_003485 NP_003476.3 Q15743 |
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