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GPR65 / TDAG8
G protein-coupled receptor 65
GPR65 (TDAG8), a Lysophospholipid/Lysosphingolipid Receptor, is a molecular target for psychosine, a toxic lipid formed by the breakdown of galactosylceramide (cerebroside). A build-up of psychosine, caused by the lack of galactosylceramidase, results in the death of the myelin-synthesizing cells, oligodendrocytes, which is associated with Krabbe disease. Recent evidence suggests that GPR65 is one of the proton-sensing GPCRs coupling to adenylyl cyclase and psychosine and its related lysosphingolipids behave as if they were antagonists against protein-sensing receptors, including TDAG8, GPR4 and OGR1 (Wang et al. 2004.)
| Gene Name: | G protein-coupled receptor 65 |
| Family/Subfamily: | GPCR , Lysophospholipid/Lysosphingolipid |
| Synonyms: | GPR65, G-protein coupled receptor 65, Gpcr25, HTDAG8, TDAG8, T-cell death-associated gene 8, Psychosine receptor, G protein-coupled receptor 65 |
| Target Sequences: | NM_003608 NP_003599.2 Q8IYL9 |
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