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GPR50 belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women.
Gene Name: | G protein-coupled receptor 50 |
Family/Subfamily: | GPCR , Orphan-A |
Synonyms: | GPR50, G protein-coupled receptor 50, Mel1c, Melatonin-related receptor, MTNRL, H9 |
Target Sequences: | NM_004224 NP_004215.2 Q13585 |
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