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High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B.
Gene Name: | G protein-coupled receptor 31 |
Family/Subfamily: | GPCR , Orphan-A |
Synonyms: | GPR31, 12-(S)-HETE acid receptor, 12-(S)-HETE receptor, 12-HETER, G-protein coupled receptor 31, HETER, HETER1, TCP10C, G protein-coupled receptor 31 |
Target Sequences: | NM_005299 NP_005290.2 O00270 |
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