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Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols. Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses. Promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Signals constitutively through G(i)-alpha, but not through G(s)-alpha or G(q)-alpha. Signals constitutively also via MAPK1/3 (ERK1/2).
Gene Name: | G protein-coupled receptor 183 |
Family/Subfamily: | GPCR , Orphan-A |
Synonyms: | GPR183, EBI 2, EBI2, EBV-induced gene 2, G protein-coupled receptor 183, G-protein coupled receptor 183 |
Target Sequences: | NM_004951 NP_004942.1 P32249 |
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