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GPR143
G protein-coupled receptor 143
Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca2+ influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport.
| Gene Name: | G protein-coupled receptor 143 |
| Family/Subfamily: | GPCR , Orphan-U |
| Synonyms: | GPR143, G-protein coupled receptor 143, G protein-coupled receptor 143, NYS6, OA1, Ocular albinism 1, Ocular albinism type 1 protein |
| Target Sequences: | NM_000273 NP_000264.2 P51810 |
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