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GPR132 / G2A
G protein-coupled receptor 132
May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity.
| Gene Name: | G protein-coupled receptor 132 |
| Family/Subfamily: | GPCR , Lysophospholipid/Lysosphingolipid |
| Synonyms: | GPR132, G2A, G protein-coupled receptor 132, G protein-coupled receptor G2A, G2 accumulation protein, G2a receptor |
| Target Sequences: | NM_013345 NP_037477.1 Q9UNW8 |
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