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Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane.
Gene Name: | glycosylphosphatidylinositol specific phospholipase D1 |
Family/Subfamily: | Phospholipase , not assigned-Phospholipase |
Synonyms: | GPLD1, Glycoprotein phospholipase D, GPI-specific phospholipase D, GPI-PLD, GPIPLD, GPIPLDM, PI-G PLD, PIGPLD1, PIGPLD |
Target Sequences: | NM_001503 NP_001494.2 P80108 |
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