GP78 / AMFR

autocrine motility factor receptor, E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

GP78 / AMFR (5)

Publications

No (5)

Tag

GST, N-terminus (1)

His-T7 (2)

Myc-DDK (Flag) (2)

Species

Human (3)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human GP78 / AMFR Protein (Recombinant His-T7) (aa456-643) - LS-G24757

Source:

E. coli

Tag:

His-T7

Molecular Weight:

25.1 kDa

Price:

10 µg/$271; 50 µg/$380; 100 µg/$607; 200 µg/$757; 1 mg/$1,810; 500 µg/$1,372; 5 mg/$2,768; 2 mg/$1,991

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Mouse GP78 / AMFR Protein (Recombinant His-T7) (aa456-639) - LS-G24758

Source:

E. coli

Tag:

His-T7

Molecular Weight:

24.8 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human GP78 / AMFR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74677

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

72.8 kDa

Price:

20 µg/$150

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Human GP78 / AMFR Protein (Recombinant GST, N-terminus) (aa451-550) - LS-G57762

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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GP78 / AMFR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118759

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

72.8 kDa

Price:

100 µg/$494

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