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GOK / STIM1
stromal interaction molecule 1
GOK / STIM1 is a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants.
| Gene Name: | stromal interaction molecule 1 |
| Synonyms: | STIM1, D11S4896E, Stromal interaction molecule 1, GOK, STIM1L |
| Target Sequences: | NM_003156 NP_003147.2 Q13586 |
Publications (4)
1
Neurokinin-neurotrophin interactions in airway smooth muscle. Meuchel LW, Stewart A, Smelter DF, Abcejo AJ, Thompson MA, Zaidi SI, Martin RJ, Prakash YS. American journal of physiology. Lung cellular and molecular physiology. 2011 301:L91-8.
[PubMed:21515660]
[PMC:PMC3129899]
2
Modification of STIM1 by O-linked N-acetylglucosamine (O-GlcNAc) attenuates store-operated calcium entry in neonatal cardiomyocytes. Zhu-Mauldin X, Marsh SA, Zou L, Marchase RB, Chatham JC. The Journal of biological chemistry. 2012 287:39094-106. (ICC; Human)
[Full Text Article]
[PubMed:22992728]
Related Antibodies: LS-B1880.
3
STIM1 R304W causes muscle degeneration and impaired platelet activation in mice. Gamage TH, Gunnes G, Lee RH, Louch WE, Holmgren A, Bruton JD, Lengle E, Kolstad TRS, Revold T, Amundsen SS, Dalen KT, Holme PA, Tjønnfjord GE, Christensen G, Westerblad H, Klungland A, Bergmeier W, Misceo D, Frengen E. Cell calcium. 2018 December;76:87-100. [Full Text Article]
[PubMed:30390422]
[PMC:PMC6481308]
Related Antibodies: LS-B10807.
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GOK / STIM1
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Publications
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(44)
Yes
(2)
GOK / STIM1 Mouse anti-Human Monoclonal (C-Terminus) (CDN3H4) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, IP, WB
Unconjugated
0.05 mg/$460
GOK / STIM1 Mouse anti-Human Monoclonal (5A2) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$440
GOK / STIM1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$515
GOK / STIM1 Sheep anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$515
GOK / STIM1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
GOK / STIM1 Goat anti-Human Polyclonal (aa231-243) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Horse, Bat, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
GOK / STIM1 Rabbit anti-Human Polyclonal (aa45-74) Antibody
Mouse, Rat, Orangutan, Human, Monkey
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
GOK / STIM1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
GOK / STIM1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
100 µg/$341
GOK / STIM1 Mouse anti-Rat Monoclonal Antibody
Rat
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
100 µg/$351
GOK / STIM1 Rabbit anti-Human Polyclonal (aa550-600) Antibody
Human
IHC, IHC-P, IP
Unconjugated
100 µl/$485
GOK / STIM1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$412
GOK / STIM1 Mouse anti-Human Monoclonal (CDN3H4) Antibody
Mouse, Rat, Human
ICC, IHC-P, IP, WB
Unconjugated
100 µg/$503
GOK / STIM1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
GOK / STIM1 Rabbit anti-Human Polyclonal (aa509-538) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
GOK / STIM1 Rabbit anti-Human Polyclonal (aa509-538) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
200 µl/$952
GOK / STIM1 Rabbit anti-Human Polyclonal (aa509-538) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
GOK / STIM1 Rabbit anti-Human Polyclonal (aa509-538) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
GOK / STIM1 Rabbit anti-Human Polyclonal (aa509-538) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
GOK / STIM1 Rabbit anti-Human Polyclonal (aa509-538) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
GOK / STIM1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
GOK / STIM1 Rabbit anti-Human Polyclonal (aa509-538) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
GOK / STIM1 Rabbit anti-Human Polyclonal (aa600-685) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$649
GOK / STIM1 Rabbit anti-Human Polyclonal (aa635-685) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
GOK / STIM1 Rabbit anti-Human Polyclonal Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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