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GNRH is secreted and then cleaved to form the 10 aa luteinizing hormone-releasing hormone (LHRH, also known as gonadoliberin-1), and prolactin release-inhibiting factor (also known as GnRH-associated peptide 1). LHRH stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutation in this gene are associated with hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been described for this gene.
Gene Name: | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) |
Family/Subfamily: | Hormone , not assigned-Hormone |
Synonyms: | GNRH1, Gonadoliberin, LHRH, LNRH, GnRH-associated peptide 1, Progonadoliberin-1, Progonadoliberin I, Luliberin I, GNRH, GRH, HH12 |
Target Sequences: | NM_000825 NP_000816.4 P01148 |
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