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GnRH receptor / GNRHR
gonadotropin-releasing hormone receptor
GnRH receptor / GNRHR is the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.
| Gene Name: | gonadotropin-releasing hormone receptor |
| Family/Subfamily: | GPCR , Releasing hormone |
| Synonyms: | GNRHR, GnRH receptor, GnRH-R, GRHR, HH7, LHRHR, LRHR, Luliberin receptor, Type I GnRH receptor, GNRHR1, Lh-rh receptor |
| Target Sequences: | NM_000406 NP_000397.1 P30968 |
Publications (1)
1
The E3 ubiquitin ligase RNF216/TRIAD3 is a key coordinator of the hypothalamic-pituitary-gonadal axis. Arlene J George, Bin Dong, Hannah Lail, Morgan Gomez, Yarely C Hoffiz, Christopher B Ware, Ning Fang, Anne Z Murphy, Erik Hrabovszky, Desiree Wanders, Angela M Mabb. iScience. 2022 June;25:104386. [Full Text Article]
[PubMed:35620441]
[PMC:PMC9126796]
Related Antibodies: LS-C383737.
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GnRH receptor / GNRHR Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
GnRH receptor / GNRHR Rabbit anti-Human Polyclonal (10-90 aa, Internal) Antibody
Mouse, Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
GnRH receptor / GNRHR Mouse anti-Human Monoclonal (Extracellular Domain) (A9E4) Antibody
Human
ELISA, Flo, IHC, IHC-Fr, WB
Unconjugated
200 µg/$757
GnRH receptor / GNRHR Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated
100 µl/$973
GnRH receptor / GNRHR Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
100 µl/$973
GnRH receptor / GNRHR Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
100 µl/$973
GnRH receptor / GNRHR Mouse anti-Human Monoclonal (PE) (A9E4) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
100 µl/$973
GnRH receptor / GNRHR Goat anti-Human Polyclonal (aa61-71) Antibody
Rabbit, Dog, Guinea pig, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
GnRH receptor / GNRHR Mouse anti-Human Monoclonal (aa1-29) (A9E4) Antibody
Human
ELISA, Flo, IHC, IHC-Fr, WB
Unconjugated
0.2 mg/$486
GnRH receptor / GNRHR Mouse anti-Human Monoclonal (aa1-29) (B470) Antibody
Human
ELISA, Flo, IHC, IHC-Fr, WB
Unconjugated
0.5 ml/$328
GnRH receptor / GNRHR Mouse anti-Human Monoclonal (aa1-29) (F1G4 or GNRH03) Antibody
Rat, Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
GnRH receptor / GNRHR Mouse anti-Human Monoclonal (aa1-29) (Azide-free, BSA-free) (F1G4 or GNRH03) Antibody
Rat, Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
GnRH receptor / GNRHR Mouse anti-Human Monoclonal (aa1-29) (Ready-to-Use) (F1G4 or GNRH03) Antibody
Rat, Human
Flo, IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$574
GnRH receptor / GNRHR Mouse anti-Human Monoclonal (aa1-29) (Concentrated) (F1G4) Antibody
Human
DB, ELISA, Flo, IHC, IHC-Fr, WB
Unconjugated, Concentrated
100 µg/$432
GnRH receptor / GNRHR Rabbit anti-Human Polyclonal (aa49-77) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
GnRH receptor / GNRHR Rabbit anti-Human Polyclonal (aa49-77) Antibody
Human
WB
Unconjugated
400 µl/$393
GnRH receptor / GNRHR Mouse anti-Human Monoclonal (GNRHR/768) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
GnRH receptor / GNRHR Mouse anti-Human Monoclonal (Azide-free, BSA-free) (GNRHR/768) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
GnRH receptor / GNRHR Mouse anti-Human Monoclonal (Ready-to-Use) (GNRHR/768) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$574
GnRH receptor / GNRHR Mouse anti-Human Monoclonal (aa1-29) (Concentrated) (A9E4) Antibody
Human
DB, ELISA, Flo, IHC, IHC-Fr, IHC-P, WB
Unconjugated, Concentrated
100 µg/$432
GnRH receptor / GNRHR Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IHC, IP, WB
Unconjugated
100 µg/$341
GnRH receptor / GNRHR Mouse anti-Human Monoclonal (Biotin) Antibody
Human
Flo, IF, IHC
Biotin Conjugated
100 µl/$1,097
GnRH receptor / GNRHR Mouse anti-Human Monoclonal (FITC) Antibody
Human
Flo, IF, IHC
FITC Conjugated
100 µl/$1,097
GnRH receptor / GNRHR Mouse anti-Human Monoclonal (PE) Antibody
Human
Flo, IF, IHC
PE Conjugated
100 µl/$1,097
GnRH receptor / GNRHR Mouse anti-Human Monoclonal (APC) Antibody
Human
Flo, IF, IHC
APC Conjugated
100 µl/$1,097
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