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The protein encoded by this gene is an allosteric enzyme that catalyzes the reversible reaction converting D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. Variations of this gene have been reported to be associated with influencing body mass index and susceptibility to obesity. A pseudogene of this gene is located on chromosome 9. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
Gene Name: | glucosamine-6-phosphate deaminase 2 |
Synonyms: | GNPDA2, GlcN6P deaminase 2, GNP2, GNPDA 2, SB52 |
Target Sequences: | NP_612208.1 Q8TDQ7 |
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