GNB3

guanine nucleotide binding protein (G protein), beta polypeptide 3

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

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Proteins (7)

Type

Over-Expression Lysate (4)

Recombinant (3)

Target

GNB3 (7)

Publications

No (7)

Tag

GST (1)

His (1)

His, N-Terminal (1)

Myc-DDK (Flag) (4)

Species

Human (5)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human GNB3 Protein (Recombinant His) - LS-G2601

Source:

E. coli

Tag:

His

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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Human GNB3 Protein (Recombinant GST) (Full Length) - LS-G28662

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

63.14 kDa

Price:

10 µg/$479; 25 µg/$670

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Human GNB3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76343

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37 kDa

Price:

20 µg/$150

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Human GNB3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76344

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37 kDa

Price:

20 µg/$150

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GNB3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99645

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37 kDa

Price:

100 µg/$494

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GNB3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G127806

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37 kDa

Price:

100 µg/$494

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Human GNB3 Protein (Recombinant His, N-Terminal) (Met1-Ala257) - LS-G133125

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

31.9kDa

Price:

10 µg/$243; 50 µg/$291; 200 µg/$402; 100 µg/$339; 1 mg/$1,156; 500 µg/$802; 5 mg/$1,982; 2 mg/$1,298

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