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GNAI1 / Gi

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.

Gene Name: guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Synonyms: GNAI1, Gi1 protein alpha subunit, Gi
Target Sequences: NM_002069 NP_002060.4 P63096

Publications (2)

1
Heterotrimeric G-protein, Gi1, is involved in the regulation of proliferation, neuronal migration, and dendrite morphology during cortical development in vivo. Nanako Hamada, Ikuko Iwamoto, Noriko Kawamura, Koh-Ichi Nagata. Journal of neurochemistry. 2021 May;157:1167-1181. [Full Text Article] [PubMed:33025585] Related Antibodies: LS-B2546.
2
Comprehensive analysis of heterotrimeric G-protein complex diversity and their interactions with GPCRs in solution. Hillenbrand M, Schori C, Sch[Character f6]ppe J, Pl[Character fc]ckthun A. Proceedings of the National Academy of Sciences of the United States of America. Mar;112:E1181-90. (WB; Spodoptera frugiperda) [Full Text Article] [PubMed:25733868] Related Antibodies: LS-C81891.

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Proteins (7)
Over-Expression Lysate (3)
Recombinant (4)
GNAI1 / Gi (7)
No (7)
6His, N-terminus (1)
GST (1)
His (1)
His, N-Terminal (1)
Myc-DDK (Flag) (3)
Human (6)
293T Cells (1)
E. coli (2)
HEK 293 Cells (3)
Wheat Germ Extract (1)
Purified (2)
GNAI1 / Gi Protein - Purified recombinant protein GNAI1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
40.2 kDa
20 µg/$1,107
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HEK 293 Cells
6His, N-terminus
44 kDa
100 µg/$298
GNAI1 / Gi Protein - 12.5% SDS-PAGE of human GNAI1 stained with Coomassie Blue
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Wheat Germ Extract
GST
64.68 kDa
10 µg/$479; 25 µg/$670
GNAI1 / Gi Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
40.2 kDa
20 µg/$150
GNAI1 / Gi Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
40.2 kDa
100 µg/$494
GNAI1 / Gi Protein
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E. coli
His, N-Terminal
40 kDa
10 µg/$265; 100 µg/$365; 50 µg/$315
GNAI1 / Gi Protein
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E. coli
His
50 µg/$361; 250 µg/$739; 10 µg/$261
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).