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GMIP is a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and stimulates RhoA-dependent GTPase activity. Alternative splicing results in multiple transcript variants.
Gene Name: | GEM Interacting Protein |
Synonyms: | GMIP, ARHGAP46, GEM interacting protein, GEM-interacting protein |
Target Sequences: | NM_016573 NP_057657.2 Q9P107 |
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