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GLRX / Glutaredoxin is a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified.
Gene Name: | glutaredoxin (thioltransferase) |
Synonyms: | GLRX, Glutaredoxin-1, Glutaredoxin, GRX1, Thioltransferase-1, GRX, TTase-1 |
Target Sequences: | NM_002064 NP_002055.1 P35754 |
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