GLRA1/Glycine Receptor Alpha 1

glycine receptor, alpha 1

Glycine is an important inhibitory transmitter in the brainstem and spinal cord. Glycine receptors are members of the ligand-gated ion channel family (LGICs) that mediate rapid chemical neurotransmission. The binding of glycine to its receptor produces a large increase in chloride conductance, which causes membrane hyperpolarization. Glycine receptors are anchored at inhibitory chemical synapses by a cytoplasmic protein, gephyrin. Gene targeting in mice showed that gephyrin is required for synaptic clustering of glycine receptors in spinal cord. The glycine receptor has been used to great advantage in the identification of the binding sites for alcohol on the LGIC family of proteins. These receptors have also been extremely useful in studies of synaptic clustering of receptors. During postnatal motor neuron development, the glycine receptor alpha subunit changes from alpha2 (fetal) to alpha1 (adult).

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Products

Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

GLRA1/Glycine Receptor Alpha 1 (4)

Publications

No (4)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human GLRA1/Glycine Receptor Alpha 1 Protein (Recombinant GST) (Full Length) - LS-G28640

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

78.1 kDa

Price:

2 µg/$439

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GLRA1/Glycine Receptor Alpha 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G98946

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.69 kDa

Price:

100 µg/$494

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Human GLRA1/Glycine Receptor Alpha 1 Protein (Recombinant GST, N-terminus) (aa121-220) - LS-G58705

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human GLRA1/Glycine Receptor Alpha 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92327

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.69 kDa

Price:

20 µg/$150

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