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GLRA1/Glycine Receptor Alpha 1

glycine receptor, alpha 1

Glycine is an important inhibitory transmitter in the brainstem and spinal cord. Glycine receptors are members of the ligand-gated ion channel family (LGICs) that mediate rapid chemical neurotransmission. The binding of glycine to its receptor produces a large increase in chloride conductance, which causes membrane hyperpolarization. Glycine receptors are anchored at inhibitory chemical synapses by a cytoplasmic protein, gephyrin. Gene targeting in mice showed that gephyrin is required for synaptic clustering of glycine receptors in spinal cord. The glycine receptor has been used to great advantage in the identification of the binding sites for alcohol on the LGIC family of proteins. These receptors have also been extremely useful in studies of synaptic clustering of receptors. During postnatal motor neuron development, the glycine receptor alpha subunit changes from alpha2 (fetal) to alpha1 (adult).

Gene Name: glycine receptor, alpha 1
Family/Subfamily: Ion Channel , Glycine receptor
Synonyms: GLRA1, Alpha 1 glycine Receptor, GlyR alpha 1, GLYRA1, SPD, STHE, Spasmodic, Glycine receptor alpha 1, Glycine receptor, alpha 1, HKPX1, Strychnine binding subunit
Target Sequences: NM_000171 NP_000162.2 P23415

Publications (1)

1
Architecture and assembly mechanism of native glycine receptors. Hongtao Zhu, Eric Gouaux. Nature. 2021 November;599:513-517. [Full Text Article] [PubMed:34555840] [PMC:PMC8647860] Related Antibodies: LS-C335282.

☰ Filters
Antibodies (21)
Proteins (4)
Over-Expression Lysate (2)
Primary (21)
Recombinant (2)
GLRA1/Glycine Receptor Alpha 1 (25)
Human (21)
Mouse (7)
Rat (5)
Bovine (1)
Chicken (1)
Dog (1)
Hamster (1)
Horse (1)
Pig (1)
Rabbit (1)
IHC (7)
IHC-P (2)
WB (18)
ELISA (10)
IF (2)
IP (1)
Peptide-ELISA (2)
rabbit (16)
mouse (3)
goat (1)
rabbit-new zealand white (1)
Product Group
IHCPlus (1)
IgG (17)
IgG1 (1)
IgG2a,k (1)
monoclonal mc (3)
polyclonal pc (18)
2E6 (1)
7F8E2 (1)
APC Conjugated (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (13)
N-Terminus (1)
aa121-221 (1)
aa29-45 (1)
aa373-386 (1)
No (24)
Yes (1)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (3)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (1)
GLRA1/Glycine Receptor Alpha 1 Antibody - Anti-GLRA1/Glycine Receptor Alpha 1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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GLRA1/Glycine Receptor Alpha 1 Goat anti-Rat Polyclonal (aa373-386) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Hamster, Pig, Horse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
GLRA1/Glycine Receptor Alpha 1 Antibody - Immunohistochemistry of paraffin-embedded human esophagus cancer tissue using GLRA1 antibody.
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GLRA1/Glycine Receptor Alpha 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
GLRA1/Glycine Receptor Alpha 1 Antibody - Immunohistochemistry of paraffin-embedded human melanoma cancer at dilution of 1:100
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GLRA1/Glycine Receptor Alpha 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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GLRA1/Glycine Receptor Alpha 1 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
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GLRA1/Glycine Receptor Alpha 1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
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GLRA1/Glycine Receptor Alpha 1 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
GLRA1/Glycine Receptor Alpha 1 Protein - 12.5% SDS-PAGE of human GLRA1 stained with Coomassie Blue
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Wheat Germ Extract
GST
78.1 kDa
2 µg/$439
GLRA1/Glycine Receptor Alpha 1 Antibody - 1:100 staining human liver carcinoma tissues by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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GLRA1/Glycine Receptor Alpha 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
GLRA1/Glycine Receptor Alpha 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
51.69 kDa
100 µg/$494
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GLRA1/Glycine Receptor Alpha 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
GLRA1/Glycine Receptor Alpha 1 Antibody - Immunohistochemistry of paraffin-embedded Human colon cancer using GLRA1 Polyclonal Antibody at dilution of 1:30.
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GLRA1/Glycine Receptor Alpha 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
GLRA1/Glycine Receptor Alpha 1 Antibody - Western blot analysis using GLRA1 mAb against HEK293 (1) and GLRA1 (AA: extra 29-154)-hIgGFc transfected HEK293 (2) cell lysate.
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GLRA1/Glycine Receptor Alpha 1 Mouse anti-Human Monoclonal (7F8E2) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$459
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GLRA1/Glycine Receptor Alpha 1 Rabbit-New Zealand White anti-Mouse Polyclonal (aa29-45) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
100 µl/$393
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GLRA1/Glycine Receptor Alpha 1 Mouse anti-Human Monoclonal (aa121-221) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$680
GLRA1/Glycine Receptor Alpha 1 Antibody - Western Blot analysis of GLRA1 expression in transfected 293T cell line by GLRA1 monoclonal antibody (M01), clone 2E6.Lane 1: GLRA1 transfected lysate(51.7 KDa).Lane 2: Non-transfected lysate.
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GLRA1/Glycine Receptor Alpha 1 Mouse anti-Human Monoclonal (2E6) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
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GLRA1/Glycine Receptor Alpha 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$331
Select
GLRA1/Glycine Receptor Alpha 1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
IP, WB
Unconjugated
200 µg/$726
Select
GLRA1/Glycine Receptor Alpha 1 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
Select
GLRA1/Glycine Receptor Alpha 1 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$937
Select
GLRA1/Glycine Receptor Alpha 1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$937
Select
GLRA1/Glycine Receptor Alpha 1 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$937
Select
GLRA1/Glycine Receptor Alpha 1 Rabbit anti-Human Polyclonal (APC) Antibody
Human
WB
APC Conjugated
100 µl/$937
Select
GLRA1/Glycine Receptor Alpha 1 Rabbit anti-Human Polyclonal (PE) Antibody
Human
WB
PE Conjugated
100 µl/$937
GLRA1/Glycine Receptor Alpha 1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
GLRA1/Glycine Receptor Alpha 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
51.69 kDa
20 µg/$150
Viewing 1-25 of 25 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).