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Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis.
Gene Name: | glyoxalase I |
Synonyms: | GLO1, Aldoketomutase, Glx I, Glyoxalase domain containing 1, Glyoxalase I, Lactoyl glutathione lyase, Lactoylglutathione lyase, GLOD1, Methylglyoxalase, Ketone-aldehyde mutase, GLYI |
Target Sequences: | NM_006708 NP_006699.2 Q04760 |
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