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GLI / GLI1

GLI family zinc finger 1

Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.

Gene Name: GLI family zinc finger 1
Synonyms: GLI1, Gli-1, GLI family zinc finger 1, Glioma-associated oncogene, Glioma-associated oncogene 1, Oncogene GLI, GLI, Zinc finger protein GLI1
Target Sequences: NM_005269 NP_005260.1 P08151

Publications (6)

1
Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis. Niemann C, Unden AB, Lyle S, Zouboulis ChC, Toftgrd R, Watt FM. Proceedings of the National Academy of Sciences of the United States of America. 2003 11873-80. [PubMed:12917489] [PMC:PMC304101]
2
Hedgehog signalling in colorectal tumour cells: induction of apoptosis with cyclopamine treatment. Qualtrough D, Buda A, Gaffield W, Williams AC, Paraskeva C. International journal of cancer. Journal international du cancer. 2004 110:831-7. [PubMed:15170664]
3
Hedgehog signaling drives cellular survival in human colon carcinoma cells. Mazumdar T, DeVecchio J, Shi T, Jones J, Agyeman A, Houghton JA. Cancer research. 2011 71:1092-102. (WB; Human) [PubMed:21135115] [PMC:PMC3032813]
4
Expression of hedgehog pathway components in prostate carcinoma microenvironment: shifting the balance towards autocrine signalling. Tzelepi V, Karlou M, Wen S, Hoang A, Logothetis C, Troncoso P, Efstathiou E. Histopathology. 2011 58:1037-47. (IHC; Human) [PubMed:21707705]
5
Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells. Mazumdar T, Devecchio J, Agyeman A, Shi T, Houghton JA. Cancer research. 2011 71:5904-14. [PubMed:21747117] [PMC:PMC3165104]
6
Hedgehog signaling inhibition by the small molecule smoothened inhibitor GDC-0449 in the bone forming prostate cancer xenograft MDA PCa 118b. Karlou M, Lu JF, Wu G, Maity S, Tzelepi V, Navone NM, Hoang A, Logothetis CJ, Efstathiou E. The Prostate. 2012 72:1638-47. (IHC; Human) [PubMed:22457212]
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Products
Antibodies (111)
Primary (111)
GLI / GLI1 (111)
Human (103)
Mouse (19)
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IHC (34)
IHC-Fr (1)
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ICC (7)
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IP (2)
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rabbit (46)
mouse (63)
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IHCPlus (2)
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IgG1 (50)
IgG2a (8)
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monoclonal mc (63)
polyclonal pc (48)
1B9F8 (1)
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4.00E+02 (1)
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aa755-1106 (46)
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aa1007-1056 (4)
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Internal Region (1)
aa1-237 (1)
aa196-230 (1)
aa768-1106 (1)
aa881-1000 (1)
aa940-990 (1)
No (111)
GLI / GLI1 Antibody - Anti-GLI1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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GLI / GLI1 Rabbit anti-Human Polyclonal (aa940-990) Antibody
Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µg/$460
GLI / GLI1 Antibody - Immunohistochemistry: Gli1 Antibody - IHC of Gli1 in mouse brain using DAB with hematoxylin counterstain.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GLI / GLI1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ICC, IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.1 ml/$386
GLI / GLI1 Antibody - Immunohistochemistry: Gli1 Antibody - IHC of Gli1 in mouse brain using DAB with hematoxylin counterstain.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GLI / GLI1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Human
ICC, IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
GLI / GLI1 Antibody - Immunohistochemistry: Gli1 Antibody - IHC of Gli1 in mouse brain using DAB with hematoxylin counterstain.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GLI / GLI1 Rabbit anti-Human Polyclonal (DY488) Antibody
Mouse, Human
ICC, IHC, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
GLI / GLI1 Antibody - Immunohistochemistry: Gli1 Antibody - IHC of Gli1 in mouse brain using DAB with hematoxylin counterstain.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GLI / GLI1 Rabbit anti-Human Polyclonal (DY650) Antibody
Mouse, Human
ICC, IHC, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
GLI / GLI1 Antibody - Immunohistochemistry: Gli1 Antibody - IHC of Gli1 in mouse brain using DAB with hematoxylin counterstain.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GLI / GLI1 Rabbit anti-Human Polyclonal (DY550) Antibody
Mouse, Human
ICC, IHC, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
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GLI / GLI1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ChrIP, ELISA, IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
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GLI / GLI1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Human
ChrIP, ELISA, IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
GLI / GLI1 Antibody - Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
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GLI / GLI1 Mouse anti-Human Monoclonal (aa755-1106) (4E2) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
GLI / GLI1 Antibody - IHC of paraffin-embedded Human skin tissue using anti-GLI1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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GLI / GLI1 Mouse anti-Human Monoclonal (aa755-1106) (OTI1C1) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
GLI / GLI1 Antibody - Immunohistochemical staining of paraffin-embedded Human skin tissue using anti-GLI1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
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GLI / GLI1 Mouse anti-Human Monoclonal (aa755-1106) (Carrier-free) (OTI1C1) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
GLI / GLI1 Antibody - IHC of paraffin-embedded Human embryonic cerebellum using anti-GLI1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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GLI / GLI1 Mouse anti-Human Monoclonal (aa1-410) (OTI2D5E2) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
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GLI / GLI1 Goat anti-Mouse Polyclonal (aa1-237) Antibody
Mouse, Human
ELISA, ICC, WB
Unconjugated
100 µg/$951
GLI / GLI1 Antibody - Fig-1: Western blot analysis of GLI1. Anti-GLI1 antibody was used at 4 µg/ml on Brain lysate.
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GLI / GLI1 Rabbit anti-Human Polyclonal (aa881-1000) Antibody
Human
WB
Unconjugated
25 µg/$281; 100 µg/$400
GLI / GLI1 Antibody - IHC of paraffin-embedded Human adult brain tissue using anti-GLI1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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GLI / GLI1 Mouse anti-Human Monoclonal (aa755-1106) (OTI4C1) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
GLI / GLI1 Antibody - IHC of paraffin-embedded Human skin tissue using anti-GLI1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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GLI / GLI1 Mouse anti-Human Monoclonal (aa755-1106) (OTI4A8) Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$434
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GLI / GLI1 Mouse anti-Human Monoclonal Antibody
Human
IP, WB
Unconjugated
100 µl/$702
GLI / GLI1 Antibody - Anti-GLI1 Antibody (N-Term) at 1:2000 dilution + NIH/3T3 whole cell lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 118 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
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GLI / GLI1 Rabbit anti-Human Polyclonal (aa196-230) Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
200 µl/$393
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GLI / GLI1 Mouse anti-Human Monoclonal (1B9F8) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$459
GLI / GLI1 Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-GLI1 mouse monoclonal antibody.  heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min)
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GLI / GLI1 Mouse anti-Human Monoclonal (aa1-410) (UMAB170) Antibody
Human
IF, IHC, PMA, WB
Unconjugated
100 µl/$493
GLI / GLI1 Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-GLI1 mouse monoclonal antibody.  heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min)
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GLI / GLI1 Mouse anti-Human Monoclonal (aa1-410) (Carrier-free) (UMAB170) Antibody
Human
IF, IHC, PMA, WB
Unconjugated, Carrier-free
100 µg/$539
GLI / GLI1 Antibody - A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GLI / GLI1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$397
GLI / GLI1 Antibody - 1:100 staining human kidney tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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GLI / GLI1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
GLI / GLI1 Antibody - Immunohistochemistry of paraffin-embedded rat testis using GLI1 antibody at dilution of 1:100 (40x lens).
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GLI / GLI1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
GLI / GLI1 Antibody - IHC of paraffin-embedded Human adult brain tissue using anti-GLI1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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GLI / GLI1 Mouse anti-Human Monoclonal (aa755-1106) (OTI2E1) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).