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GLB1 / Beta-Galactosidase
galactosidase, beta 1
Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.Isoform 2 has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers.
| Gene Name: | galactosidase, beta 1 |
| Synonyms: | GLB1, Acid beta-galactosidase, Beta-galactosidase, Elastin receptor 1, Elastin receptor 1 (67kD), Elastin receptor 1, 67kDa, Galactosidase, beta 1, ELNR1, Lactase, MPS4B |
| Target Sequences: | NM_000404 NP_000395.2 P16278 |
Publications (5)
1
SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination. Lu W, Liu S, Li B, Xie Y, Adhiambo C, Yang Q, Ballard BR, Nakayama KI, Matusik RJ, Chen Z. Oncotarget. 2015 6:771-88. (WB; Human)
[PubMed:25596733]
[PMC:PMC4359254]
2
DNA Hypomethylation and Histone Variant macroH2A1 Synergistically Attenuate Chemotherapy-Induced Senescence to Promote Hepatocellular Carcinoma Progression. Borghesan M, Fusilli C, Rappa F, Panebianco C, Rizzo G, Oben JA, Mazzoccoli G, Faulkes C, Pata I, Agodi A, Rezaee F, Minogue S, Warren A, Peterson A, Sedivy JM, Douet J, Buschbeck M, Cappello F, Mazza T, Pazienza V, Vinciguerra M. Cancer research. 2016 76:594-606. (WB; Human)
[Full Text Article]
[PubMed:26772755]
[PMC:PMC4785885]
Related Antibodies: LS-B10217.
3
Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer. Kovacovicova K, Skolnaja M, Heinmaa M, Mistrik M, Pata P, Pata I, Bartek J, Vinciguerra M. Frontiers in oncology. 2018 October;8:459. [Full Text Article]
[PubMed:30425964]
[PMC:PMC6218402]
Related Antibodies: LS-B10217.
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GLB1 / Beta-Galactosidase Mouse anti-Human Monoclonal (5H2) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
GLB1 / Beta-Galactosidase Mouse anti-Human Monoclonal (10B2) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
GLB1 / Beta-Galactosidase Mouse anti-Human Monoclonal (2F6) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$440
GLB1 / Beta-Galactosidase Mouse anti-Human Monoclonal (OTI1E10) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
GLB1 / Beta-Galactosidase Mouse anti-Human Monoclonal (Carrier-free) (OTI1E10) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
GLB1 / Beta-Galactosidase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
Sandwich
96-Well Strip Plate
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
Sandwich
96-Well Strip Plate
Human
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
74.63kD
10 µg/$297; 50 µg/$468; 500 µg/$1,585; 1 mg/$2,157
GLB1 / Beta-Galactosidase Rabbit Polyclonal Antibody
ICC, IHC, IP, WB
Unconjugated
100 µl/$425
GLB1 / Beta-Galactosidase Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$321
GLB1 / Beta-Galactosidase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
GLB1 / Beta-Galactosidase Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
GLB1 / Beta-Galactosidase Mouse anti-Human Monoclonal (6E7) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$423
GLB1 / Beta-Galactosidase Rabbit anti-Human Polyclonal (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$937
GLB1 / Beta-Galactosidase Mouse Monoclonal (5A3) Antibody
ICC, IHC, IP, WB
Unconjugated
100 µg/$413
GLB1 / Beta-Galactosidase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
GLB1 / Beta-Galactosidase Mouse anti-Human Monoclonal (Carrier-free) (5H2) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
GLB1 / Beta-Galactosidase Rabbit anti-Human Polyclonal (aa68-219) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$334; 200 µl/$387; 500 µl/$565; 1 ml/$682; 2 ml/$919; 5 ml/$1,549
GLB1 / Beta-Galactosidase Mouse anti-Human Monoclonal (Carrier-free) (2F6) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
GLB1 / Beta-Galactosidase Mouse anti-Human Monoclonal (OTI1C9) Antibody
Dog, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$450
GLB1 / Beta-Galactosidase Mouse anti-Human Monoclonal (Carrier-free) (OTI1C9) Antibody
Dog, Human, Monkey
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 mIU/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Microplate
Mouse
0.156 - 10 mU/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
Sandwich CLIA
12 x 8-Well Microstrips
Rat
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
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