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GJB2 / CX26 / Connexin 26
gap junction protein, beta 2, 26kDa
GJB2 / CX26 / Connexin 26 is a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness.
| Gene Name: | gap junction protein, beta 2, 26kDa |
| Family/Subfamily: | Ion Channel , Connexin |
| Synonyms: | GJB2, Connexin 26, Connexin-26, DFNB1A, DFNA3, DFNB1, Gap junction protein beta 2, KID, HID, PPK, NSRD1, CX26, DFNA3A |
| Target Sequences: | NM_004004 NP_003995.2 P29033 |
Publications (3)
1
Mouse middle ear ion homeostasis channels and intercellular junctions. Morris LM, DeGagne JM, Kempton JB, Hausman F, Trune DR. PloS one. 2012 7:e39004. (IHC-P; Mouse)
[PubMed:22720014]
[PMC:PMC3376096]
Related Antibodies: LS-C14526.
2
Assembly of the cochlear gap junction macromolecular complex requires connexin 26. Kamiya K, Yum SW, Kurebayashi N, Muraki M, Ogawa K, Karasawa K, Miwa A, Guo X, Gotoh S, Sugitani Y, Yamanaka H, Ito-Kawashima S, Iizuka T, Sakurai T, Noda T, Minowa O, Ikeda K. The Journal of clinical investigation. 2014 124:1598-607. (WB; Mouse)
[Full Text Article]
[PubMed:24590285]
[PMC:PMC3973107]
Related Antibodies: LS-B6429.
3
Mammary gland specific knockdown of the physiological surge in Cx26 during lactation retains normal mammary gland development and function. Stewart MK, Plante I, Bechberger JF, Naus CC, Laird DW. PloS one. 2014 9:e101546. (WB; Rat)
[Full Text Article]
[PubMed:24988191]
[PMC:PMC4079510]
Related Antibodies: LS-B5511.
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Antibodies
(43)
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Primary
(43)
Target
GJB2 / CX26 / Connexin 26
(43)
Reactivity
Human
(39)
Mouse
(30)
Rat
(21)
Bat
(1)
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(3)
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(3)
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(5)
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(3)
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(3)
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(1)
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(4)
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(2)
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(3)
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(1)
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(21)
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(2)
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(4)
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(37)
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(28)
ICC
(2)
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(4)
IP
(2)
Peptide-ELISA
(3)
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rabbit
(34)
mouse
(8)
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(1)
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(3)
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IgG
(28)
IgG1,k
(6)
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(1)
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(1)
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monoclonal mc
(8)
polyclonal pc
(35)
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1C6
(1)
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(1)
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(2)
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(1)
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(4)
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(4)
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(4)
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(1)
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(2)
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(1)
Unconjugated
(25)
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aa204-226
(7)
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(5)
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(4)
aa85-134
(4)
Cytoplasmic Domain
(2)
aa1-16
(1)
aa212-225
(1)
aa45-94
(1)
Publications
No
(40)
Yes
(3)
GJB2 / CX26 / Connexin 26 Mouse anti-Mouse Monoclonal (C-Terminus) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$485
GJB2 / CX26 / Connexin 26 Mouse anti-Rat Monoclonal (Cytoplasmic Domain) (CX-12H10) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50 µg/$485
GJB2 / CX26 / Connexin 26 Mouse anti-Rat Monoclonal (Biotin) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Biotin Conjugated
100 µl/$1,054
GJB2 / CX26 / Connexin 26 Mouse anti-Rat Monoclonal (FITC) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
FITC Conjugated
100 µl/$1,054
GJB2 / CX26 / Connexin 26 Mouse anti-Rat Monoclonal (APC) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
APC Conjugated
100 µl/$1,054
GJB2 / CX26 / Connexin 26 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse, Rat
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$786
GJB2 / CX26 / Connexin 26 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
GJB2 / CX26 / Connexin 26 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
GJB2 / CX26 / Connexin 26 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
GJB2 / CX26 / Connexin 26 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
ELISA, WB
Unconjugated
100 µl/$801
GJB2 / CX26 / Connexin 26 Rabbit anti-Human Polyclonal (aa204-226) Antibody
Mouse, Human
IHC, WB
Unconjugated
400 µl/$393
GJB2 / CX26 / Connexin 26 Rabbit anti-Rat Polyclonal (Internal) Antibody
Mouse, Rat, Human
ICC, WB
Unconjugated
100 µg/$380
GJB2 / CX26 / Connexin 26 Rabbit anti-Human Polyclonal (Internal) (Sepharose) Antibody
Mouse, Rat, Human
IP
Sepharose Conjugated
100 µg/$399
GJB2 / CX26 / Connexin 26 Rabbit anti-Rat Polyclonal (Cytoplasmic Domain) Antibody
Rat
ELISA, IF, IHC, IHC-Fr, WB
Unconjugated
50 µg/$786
GJB2 / CX26 / Connexin 26 Rabbit anti-Human Polyclonal (aa204-226) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
GJB2 / CX26 / Connexin 26 Rabbit anti-Human Polyclonal (aa204-226) (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
GJB2 / CX26 / Connexin 26 Rabbit anti-Human Polyclonal (aa204-226) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
GJB2 / CX26 / Connexin 26 Rabbit anti-Human Polyclonal (aa204-226) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
GJB2 / CX26 / Connexin 26 Rabbit anti-Human Polyclonal (aa204-226) (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
GJB2 / CX26 / Connexin 26 Rabbit anti-Human Polyclonal (aa204-226) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
GJB2 / CX26 / Connexin 26 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
GJB2 / CX26 / Connexin 26 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
GJB2 / CX26 / Connexin 26 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$832
GJB2 / CX26 / Connexin 26 Rabbit anti-Human Polyclonal Antibody
Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
GJB2 / CX26 / Connexin 26 Mouse anti-Human Monoclonal (1C6) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
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