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GJA1 / CX43 / Connexin 43

gap junction protein, alpha 1, 43kDa

Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract.

Gene Name: gap junction protein, alpha 1, 43kDa
Family/Subfamily: Ion Channel , Connexin
Synonyms: GJA1, Connexin-43, DFNB38, Connexin 43, Gap junction alpha-1 protein, GJAL, HSS, Gap junction protein alpha 1, ODDD, ODD, AVSD3, CX43, HLHS1, ODOD, SDTY3
Target Sequences: NM_000165 NP_000156.1 P17302

Publications (4)

1
Connexin 43 controls the multipolar phase of neuronal migration to the cerebral cortex. Liu X, Sun L, Torii M, Rakic P. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:8280-5. [PubMed:22566616] [PMC:PMC3361458] Related Antibodies: LS-C97725.
2
Inhibition of Connexin 43 and Phosphorylated NR2B in Spinal Astrocytes Attenuates Bone Cancer Pain in Mice. Yang H, Yan H, Li X, Liu J, Cao S, Huang B, Huang D, Wu L. Frontiers in cellular neuroscience. 2018 May;12:129. (Rat) [Full Text Article] [PubMed:29867362] [PMC:PMC5951934] Related Antibodies: LS-B9771.
3
Structural alterations and inflammation in the heart after multiple trauma followed by reamed versus non-reamed femoral nailing. Meike Baur, Birte Weber, Ina Lackner, Florian Gebhard, Roman Pfeifer, Paolo Cinelli, Sascha Halvachizadeh, Michel Teuben, Miriam Lipiski, Nikola Cesarovic, Hans-Christoph Pape, Miriam Kalbitz. PloS one. 2020 June;15:e0235220. [Full Text Article] [PubMed:32584885] [PMC:PMC7316303]
4
Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy. Hung X Nguyen , Tianyu Wu , Daniel Needs, Hengtao Zhang, Robin M Perelli, Sophia DeLuca, Rachel Yang, Michael Tian, Andrew P Landstrom, Craig Henriquez, Nenad Bursac. Nature communications. 2022 February;13:620. [Full Text Article] [PubMed:35110560] [PMC:PMC8810800] Related Antibodies: LS-B9770.
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Proteins (5)
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GJA1 / CX43 / Connexin 43 (5)
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GJA1 / CX43 / Connexin 43 Protein - Recombinant Connexin 43 By SDS-PAGE
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E. coli
His, N-Terminal
26.2 kDa
10 µg/$277; 50 µg/$420; 100 µg/$670; 200 µg/$837; 1 mg/$1,928; 500 µg/$1,474; 5 mg/$2,927; 2 mg/$2,113
GJA1 / CX43 / Connexin 43 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
42.8 kDa
20 µg/$150
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E. coli
His
20.4 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
GJA1 / CX43 / Connexin 43 Protein - Recombinant Connexin 43 By SDS-PAGE
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E. coli
His, N-Terminal
26.1 kDa
10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225
GJA1 / CX43 / Connexin 43 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
42.8 kDa
100 µg/$494
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).