GIPR / GIP Receptor

gastric inhibitory polypeptide receptor

GIPR, or Gastric Inhibitory Polypeptide Receptor, mediates GIP-induced secretion of insulin by pancreatic islet beta cells after a meal. GIP is a gastrointestinal peptide hormone of 42 aa that is released from duodenal endocrine K cells after absorption of glucose or fat. Stimulation of the GIPR on pancreatic cells activates adenylyl cyclase and mitogen-activated protein kinase, resulting in increased insulin secretion. Mice with a targeted mutation of GIPR have higher blood glucose levels with impaired initial insulin response after oral glucose load. Analysis of GIPR knockout mice suggest that GIPR defects may contribute to the pathogenesis of diabetes and obesity. Ectopic expression of functional GIPR and its coupling to steroidogenesis has been suggested to be the main cause of food-dependent Cushing's syndrome. Two isoforms of GIPR are produced by alternative splicing.

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Proteins (2)

Type

Over-Expression Lysate (2)

Target

GIPR / GIP Receptor (2)

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No (2)

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Myc-DDK (Flag) (2)

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Human (1)

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293T Cells (1)

HEK 293 Cells (1)

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Human GIPR / GIP Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76108

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53 kDa

Price:

20 µg/$150

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GIPR / GIP Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G98944

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53 kDa

Price:

100 µg/$494

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