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GHRHR, a Growth Hormone-Releasing Hormone Receptor, is involved in the proliferation and differentiation of somatotrophic pituitary cells and in disease. The GHRH receptor stimulates growth hormone (GH) secretion and synthesis in the pituitary. Mutations in this receptor cause either growth-hormone deficiency, resulting in dwarfism, or excessive production of the hormone, leading to gigantism. Four alternative splice variants have been identified that are tissue specific.
Gene Name: | growth hormone releasing hormone receptor |
Family/Subfamily: | GPCR , Growth hormone releasing hormone |
Synonyms: | GHRHR, GHRFR, GRFR, IGHD1B, GRF receptor, GH-releasing hormone receptor, GHRH receptor, Ghrh-r |
Target Sequences: | NM_000823 NP_000814.2 Q02643 |
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