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Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.
Gene Name: | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) |
Family/Subfamily: | Protease , Cysteine C26 |
Synonyms: | GGH, Gamma-Glu-X carboxypeptidase, Gamma-glutamyl hydrolase, GH, Conjugase |
Target Sequences: | NM_003878 NP_003869.1 Q92820 |
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