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GGCX is an enzyme which catalyzes the posttranslational modification of vitamin K-dependent protein. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis. Mutations in this gene are associated with vitamin K-dependent coagulation defect and PXE-like disorder with multiple coagulation factor deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene Name: | gamma-glutamyl carboxylase |
Synonyms: | GGCX, Gamma-glutamyl carboxylase, VKCFD1 |
Target Sequences: | NM_000821 NP_000812.2 P38435 |
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