Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence of a novel glycosylphosphadidylinositol linked protein NTNRa, which is a cell surface receptor for NTN. The cDNAs encoding NTNRa from human, rat, chicken, and mouse have been cloned recently (2-7). NTNRa was also termed GDNFRb, Ret ligand 2 (RETL2) or TGF-b-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRa-2 recently. GFRa-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRa-2, and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.
Gene Name: | GDNF family receptor alpha 2 |
Family/Subfamily: | GDNF Receptor , Not assigned-Other |
Synonyms: | GFRA2, GDNF receptor alpha-2, GDNFRB, GFR-alpha 2, GFR-alpha-2, GDNF family receptor alpha-2, GDNFR-beta, GDNF family receptor alpha 2, Neurturin receptor alpha, RET ligand 2, TRNR2, TRN receptor, GPI-anchored, NTNR-alpha, NTNRA, GDNF receptor beta, GDNFR-alpha-2, NRTNR-ALPHA, RETL2 |
Target Sequences: | NM_001495 NP_001486.4 O00451 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.