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Location
Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
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GFER
growth factor, augmenter of liver regeneration
Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen.Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration.
| Gene Name: | growth factor, augmenter of liver regeneration |
| Synonyms: | GFER, ERV1, HPO1, HPO2, HPO, HSS, Hepatopoietin, ALR, ERV1 homolog, Erv1-like growth factor, Hepatopoietin protein, HERV1 |
| Target Sequences: | NM_005262 NP_005253.3 P55789 |
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