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GEN1

GEN1 Holliday junction 5' flap endonuclease

Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation.

Gene Name: GEN1 Holliday junction 5' flap endonuclease
Synonyms: GEN1, Gen homolog 1, endonuclease, Gen
Target Sequences: NM_001130009 NP_001123481.1 Q17RS7

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).