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Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation.
Gene Name: | GEN1 Holliday junction 5' flap endonuclease |
Synonyms: | GEN1, Gen homolog 1, endonuclease, Gen |
Target Sequences: | NM_001130009 NP_001123481.1 Q17RS7 |
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