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Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. May signal through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A.
Gene Name: | growth differentiation factor 6 |
Family/Subfamily: | TGF beta |
Synonyms: | GDF6, BMP13, CDMP2, GDF16, KFS1, KFM, Klippel-Feil syndrome, MCOP4, KFSL, Klip-Feil malformation, Klippel-Feil malformation, SGM1, MCOPCB6, SCDO4, GDF-6, KFS |
Target Sequences: | NM_001001557 NP_001001557.1 Q6KF10 |
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