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Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.
Gene Name: | glutamate-cysteine ligase, modifier subunit |
Synonyms: | GCLM, Gamma-ECS regulatory subunit, GLCLR, GCS light chain, GSC light chain |
Target Sequences: | NM_002061 NP_002052.1 P48507 |
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