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GCLC
glutamate-cysteine ligase, catalytic subunit
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
| Gene Name: | glutamate-cysteine ligase, catalytic subunit |
| Synonyms: | GCLC, GCL, GCS heavy chain, Gamma-ECS, GCS, GLCL, GLCLC |
| Target Sequences: | NM_001498 NP_001489.1 P48506 |
Publications (1)
1
Cr(VI)-induced DNA damage is lessened by the modulation of hsp70 via increased GSH de novo synthesis in Drosophila melanogaster. Hitesh S Chaouhan, Rakesh R Jha, Devendra K Patel, Debapratim Kar Chowdhuri. Journal of biochemical and molecular toxicology. 2021 August;35:e22819. [Full Text Article]
[PubMed:34056787]
Related Antibodies: LS-C458774.
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GCLC Rabbit anti-Rat Polyclonal (aa295-313) Antibody
Mouse, Bovine, Rat, Human, Monkey
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$485
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
GCLC Rabbit anti-Human Polyclonal (aa323-372) (HRP) Antibody
Xenopus, Chicken, Zebrafish, Drosophila, Pig, Horse, Bat, Rat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
GCLC Rabbit anti-Human Polyclonal (aa323-372) (FITC) Antibody
Xenopus, Chicken, Zebrafish, Drosophila, Pig, Horse, Bat, Rat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
GCLC Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$748
Sandwich
96-Well Microplate
Human
0.23 - 15 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
GCLC Rabbit anti-Human Polyclonal (aa286-315) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
GCLC Rabbit anti-Human Polyclonal (aa437-637) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
GCLC Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
200 µl/$734
GCLC Rabbit anti-Human Polyclonal (aa1-30) (Biotin) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
GCLC Rabbit anti-Human Polyclonal (aa1-30) (FITC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
GCLC Rabbit anti-Human Polyclonal (aa1-30) (APC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
GCLC Rabbit anti-Human Polyclonal (aa1-30) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
GCLC Rabbit anti-Human Polyclonal (aa1-30) (PE) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
GCLC Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
GCLC Rabbit anti-Human Polyclonal (aa74-123) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
GCLC Rabbit anti-Human Polyclonal (aa74-123) (Biotin) Antibody
Zebrafish, Rat, Hamster, Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Bat, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
![GCLC Antibody - Immunofluorescence of monoclonal antibody to GCLC on HeLa cell. [antibody concentration 10 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/gclc-antibody-clone-3h1-ls-c197304/145028_4894767.jpg)
GCLC Mouse anti-Human Monoclonal (3H1) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
GCLC Mouse anti-Human Monoclonal (OTI1A3) Antibody
Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$434
GCLC Mouse anti-Human Monoclonal (Carrier-free) (OTI1A3) Antibody
Rat, Human, Monkey
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
GCLC Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
GCLC Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Pig, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
GCLC Rabbit anti-Human Polyclonal (aa7-24) Antibody
Rabbit, Human, Monkey
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
GCLC Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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