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Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity.
Gene Name: | glucokinase (hexokinase 4) regulator |
Synonyms: | GCKR, GKRP, FGQTL5, Glucokinase regulator, Glucokinase regulatory protein |
Target Sequences: | NM_001486 NP_001477.2 Q14397 |
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