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GCK / Glucokinase

glucokinase (hexokinase 4)

Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.

Gene Name: glucokinase (hexokinase 4)
Synonyms: GCK, FGQTL3, Glucokinase, HK IV, HKIV, Hexokinase d, liver isozymes, Hexokinase-4, Hexokinase-D, HXKP, GLK, Glucokinase (hexokinase 4), Hexokinase type IV, HHF3, HK4, LGLK, MODY2
Target Sequences: NM_000162 NP_000153.1 P35557

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Products
Proteins (16)
Over-Expression Lysate (6)
Recombinant (10)
GCK / Glucokinase (16)
SDS-PAGE (1)
No (16)
GST (1)
GST, N-terminus (1)
His (1)
His-GST, N-terminus (1)
His-T7 (1)
Myc-DDK (Flag) (9)
Human (11)
Mouse (1)
Rat (1)
293T Cells (3)
E. coli (5)
HEK 293 Cells (6)
Wheat Germ Extract (2)
Purified (2)
GCK / Glucokinase Protein
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E. coli
His
54.3 kDa
100 µg/$511; 500 µg/$1,348; 20 µg/$311
GCK / Glucokinase Protein - Recombinant  Glucokinase By SDS-PAGE
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E. coli
His-T7
29.2 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
GCK / Glucokinase Protein
Select
E. coli
None
SDS-PAGE
The recombinant human GCK isoform 1 consists of 466 amino acids and predicts a molecular mass of 52.2 kDa as estimated in SDS-PAGE under reducing conditions.
50 µg/$410
GCK / Glucokinase Protein - Purified recombinant protein GCK was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
52 kDa
20 µg/$1,107
GCK / Glucokinase Protein - Purified recombinant protein GCK was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
51.9 kDa
20 µg/$1,107
GCK / Glucokinase Protein - Purified recombinant protein GCK was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
52 kDa
20 µg/$1,107
GCK / Glucokinase Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
GCK / Glucokinase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
52 kDa
100 µg/$494
GCK / Glucokinase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
51.9 kDa
100 µg/$710
Select
293T Cells
Myc-DDK (Flag)
52 kDa
20 µg/$150
GCK / Glucokinase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
51.9 kDa
20 µg/$215
GCK / Glucokinase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
52 kDa
20 µg/$215
GCK / Glucokinase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
52 kDa
100 µg/$710
GCK / Glucokinase Protein - Recombinant Glucokinase (GCK) by SDS-PAGE
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E. coli
His-GST, N-terminus
54.1kDa
10 µg/$278; 50 µg/$422; 200 µg/$842; 100 µg/$672; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
Select
E. coli
None
52.2 kDa
50 µg/$707
GCK / Glucokinase Protein - 12.5% SDS-PAGE of human GCK stained with Coomassie Blue
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Wheat Germ Extract
GST
76.78 kDa
10 µg/$479; 25 µg/$670
Viewing 1-16 of 16 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).