GCG / Glucagon

Glucagon

Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes.GLP-1 is a potent stimulator of glucose-dependent insulin release. Play important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Have growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis.GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability.Oxyntomodulin significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness.Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.

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Proteins (14)

Type

Over-Expression Lysate (2)

Recombinant (12)

Target

GCG / Glucagon (14)

Publications

No (14)

Tag

6His, C-terminus (2)

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

GST-6His, N-terminus (1)

His (2)

His, N-Terminal (2)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (11)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (7)

HEK 293 Cells (2)

Human Cells (1)

Mammalian Cells (1)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (3)

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Human GCG / Glucagon Protein (Recombinant 6His, N-terminus) (Arg21-Lys180) - LS-G26549

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

20.9 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365; 250 µg/$518

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Rat GCG / Glucagon Protein (Recombinant His, N-Terminal) (aa21-180) - LS-G13585

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

22.4 kDa

Price:

10 µg/$277; 50 µg/$420; 200 µg/$837; 1 mg/$1,928; 5 mg/$2,927; 2 mg/$2,113

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Mouse GCG / Glucagon Protein (Recombinant His, N-Terminal) (aa21-180) - LS-G24259

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

22.3 kDa

Price:

10 µg/$271; 50 µg/$382; 200 µg/$762; 1 mg/$1,817; 5 mg/$2,775; 2 mg/$1,998

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Human GCG / Glucagon Protein (Recombinant 6His, C-terminus) (Arg21-Lys180) - LS-G39117

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

18.6kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157

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Human GCG / Glucagon Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65716

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

18.6 kDa

Price:

20 µg/$1,107

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Human GCG / Glucagon Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76141

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20.91 kDa

Price:

20 µg/$150

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GCG / Glucagon Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118217

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20.91 kDa

Price:

100 µg/$494

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Human GCG / Glucagon Protein (Recombinant GST, N-terminus) - LS-G137025

Source:

E. coli

Tag:

GST, N-terminus

Molecular Weight:

30.4 kDa

Price:

1 mg/$1,486; 100 µg/$451; 20 µg/$339

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Human GCG / Glucagon Protein (Recombinant GST-6His, N-terminus) - LS-G137028

Source:

E. coli

Tag:

GST-6His, N-terminus

Molecular Weight:

34.4 kDa

Price:

1 mg/$1,486; 100 µg/$451; 20 µg/$339

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Human GCG / Glucagon Protein (Recombinant 6His, C-terminus) (Arg21-Lys180) - LS-G140178

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

18.6 kDa

Price:

10 µg/$344; 50 µg/$584

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Human GCG / Glucagon Protein (Recombinant His) (aa53-89) - LS-G22929

Source:

Yeast

Tag:

His

Molecular Weight:

6.4 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human GCG / Glucagon Protein (Recombinant His) - LS-G1363

Source:

E. coli

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human GCG / Glucagon Protein (Recombinant GST) (Full Length) - LS-G28594

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

45.54 kDa

Price:

10 µg/$479; 25 µg/$670

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Human GCG / Glucagon Protein (Recombinant His-T7) (aa23-180) - LS-G13586

Source:

E. coli

Tag:

His-T7

Molecular Weight:

21.9 kDa

Price:

10 µg/$263; 50 µg/$343; 100 µg/$530; 200 µg/$662; 1 mg/$1,657; 500 µg/$1,242; 5 mg/$2,600; 2 mg/$1,832

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