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Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.
Gene Name: | germinal center-associated, signaling and motility |
Synonyms: | GCSAM, HGAL, GCAT2, GCET2 |
Target Sequences: | Q8N6F7 Q8N6F7 |
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