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GAPIII / RASA3 is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane.
Gene Name: | RAS p21 protein activator 3 |
Synonyms: | RASA3, GAPIII, GAP1(IP4BP), GTPase activating protein III, Ins(1,3,4,5)P4-binding protein, GAP1IP4BP, Ins P4-binding protein, RAS p21 protein activator 3 |
Target Sequences: | NM_007368 NP_031394.2 Q14644 |
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