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GAP43

growth associated protein 43

This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.

Gene Name: growth associated protein 43
Family/Subfamily: Neuromodulin , Not assigned-Other
Synonyms: GAP43, Axonal membrane protein GAP-43, B-50, Growth associated protein 43, Growth-associated protein 43, Neural phosphoprotein B-50, Neuromodulin, PP46, GAP-43, Protein F1
Target Sequences: NM_002045 NP_002036.1 P17677

Publications (15)

1
Axonal regeneration into acellular nerve grafts is enhanced by degradation of chondroitin sulfate proteoglycan. Krekoski CA, Neubauer D, Zuo J, Muir D. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001 21:6206-13. [PubMed:11487643]
2
Regeneration of axons after nerve transection repair is enhanced by degradation of chondroitin sulfate proteoglycan. Zuo J, Neubauer D, Graham J, Krekoski CA, Ferguson TA, Muir D. Experimental neurology. 2002 176:221-8. [PubMed:12093099]
3
Loss of a FYN-regulated differentiation and growth arrest pathway in advanced stage neuroblastoma. Berwanger B, Hartmann O, Bergmann E, Bernard S, Nielsen D, Krause M, Kartal A, Flynn D, Wiedemeyer R, Schwab M, Schfer H, Christiansen H, Eilers M. Cancer cell. 2002 2:377-86. [PubMed:12450793]
4
Metalloproteinase-dependent predegeneration in vitro enhances axonal regeneration within acellular peripheral nerve grafts. Krekoski CA, Neubauer D, Graham JB, Muir D. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2002 22:10408-15. [PubMed:12451140]
5
Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation. Teo JL, Ma H, Nguyen C, Lam C, Kahn M. Proceedings of the National Academy of Sciences of the United States of America. 2005 102:12171-6. [PubMed:16093313] [PMC:PMC1189325]
6
Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system. Osterfield M, Egelund R, Young LM, Flanagan JG. Development (Cambridge, England). 2008 135:1189-99. [PubMed:18272596]
7
Wnt/Frizzled family members mediate olfactory sensory neuron axon extension. Rodriguez-Gil DJ, Greer CA. The Journal of comparative neurology. 2008 511:301-17. (IHC; Mouse) [PubMed:18803244] [PMC:PMC2570497]
8
Composition of the migratory mass during development of the olfactory nerve. Miller AM, Treloar HB, Greer CA. The Journal of comparative neurology. 2010 518:4825-41. [PubMed:21031554]
9
Renal cystic disease proteins play critical roles in the organization of the olfactory epithelium. Pluznick JL, Rodriguez-Gil DJ, Hull M, Mistry K, Gattone V, Johnson CA, Weatherbee S, Greer CA, Caplan MJ. PloS one. 2011 6:e19694. (ICC, IHC, IHC-Fr; Mouse, Rat) [PubMed:21614130] [PMC:PMC3094399]
10
Impaired sprouting and axonal atrophy in cerebellar climbing fibres following in vivo silencing of the growth-associated protein GAP-43. Grasselli G, Mandolesi G, Strata P, Cesare P. PloS one. 2011 6:e20791. [PubMed:21695168] [PMC:PMC3112224]
11
Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription. Murakami M, Ito H, Hagiwara K, Kobayashi M, Hoshikawa A, Takagi A, Kojima T, Tamiya-Koizumi K, Sobue S, Ichihara M, Suzuki M, Banno Y, Nozawa Y, Murate T. Journal of cellular biochemistry. 2011 112:3449-58. (WB; Human) [PubMed:21769916]
12
Fas-associated factor 1 as a regulator of olfactory axon guidance. Cheng K, Bai L, Belluscio L. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:11905-13. [PubMed:21849551] [PMC:PMC3184845]
13
In vivo olfactory model of APP-induced neurodegeneration reveals a reversible cell-autonomous function. Cheng N, Cai H, Belluscio L. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:13699-704. [PubMed:21957232] [PMC:PMC3190161]
14
IgSF8: a developmentally and functionally regulated cell adhesion molecule in olfactory sensory neuron axons and synapses. Ray A, Treloar HB. Molecular and cellular neurosciences. 2012 50:238-49. (ICC, IHC; Mouse) [PubMed:22687584] [PMC:PMC3418437]
15
Critical role of GFR1 in the development and function of the main olfactory system. Marks C, Belluscio L, Ibez CF. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 32:17306-20. (ICC, IHC; Mouse) [PubMed:23197722]
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Antibodies (95)
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GAP43 Antibody - Anti-GAP43 antibody IHC of human brain, putamen, neuropil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Neuroscience
GAP43 Mouse anti-Rat Monoclonal Antibody
Chicken, Rabbit, Mouse, Rat, Human, Snake
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50 µg/$485
GAP43 Antibody - Immunohistochemical analysis of GAP43 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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GAP43 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Chicken, Zebrafish, Mouse, Rat, Bovine, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
GAP43 Antibody - Western Blot analysis of GAP43 expression in transfected 293T cell line by GAP43 monoclonal antibody (M01), clone 3C11.Lane 1: GAP43 transfected lysate(24.8 KDa).Lane 2: Non-transfected lysate.
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GAP43 Mouse anti-Human Monoclonal (3C11) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
GAP43 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$715
GAP43 ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
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GAP43 Sheep anti-Human Polyclonal (pSer41) Antibody
Mouse, Rat, Human
IHC
Unconjugated
500 µg/$393
GAP43 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
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GAP43 Mouse anti-Human Monoclonal (6F2) Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
GAP43 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
GAP43 Protein
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E. coli
6His, N-terminus
26.5 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
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GAP43 Rabbit anti-Human Polyclonal (aa1-238) Antibody
Human
ELISA
Unconjugated
50 µl/$294; 100 µl/$360
GAP43 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
GAP43 Protein
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E. coli
His
20 µg/$361; 100 µg/$739; 4 µg/$261
GAP43 Antibody - Immunochemical staining of human GAP43 in human brain with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.
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GAP43 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA, IHC-P, IP, WB
Unconjugated, Preservative Free
100 µl/$412
GAP43 Antibody - Human Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
GAP43 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$460
GAP43 Antibody - Mixed neuron-glial cultures stained with GAP43 antibody (green) and rabbit antibody to alpha-II spectrin (red), and DNA (blue). The GAP43 antibody stains numerous axonal and dendritic profiles in these cultures, clearly revealing the submembranous cytoskeleton and vesicles.
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GAP43 Chicken anti-Rat Polyclonal (aa216-226) Antibody
Mouse, Rat
ICC, IF, WB
Unconjugated
100 µl/$376
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GAP43 Rabbit anti-Rat Polyclonal Antibody
Chicken, Bovine, Mouse, Rat, Human
ELISA, ICC, IHC, IP, WB
Unconjugated
100 µl/$896
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GAP43 Rabbit anti-Rat Polyclonal (Biotin) Antibody
Chicken, Bovine, Mouse, Rat, Human
ELISA, ICC, IHC, IP, WB
Biotin Conjugated
100 µl/$1,109
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GAP43 Rabbit anti-Rat Polyclonal (FITC) Antibody
Chicken, Bovine, Mouse, Rat, Human
ELISA, ICC, IHC, IP, WB
FITC Conjugated
100 µl/$1,109
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GAP43 Rabbit anti-Rat Polyclonal (APC) Antibody
Chicken, Bovine, Mouse, Rat, Human
ELISA, ICC, IHC, IP, WB
APC Conjugated
100 µl/$1,109
Select
GAP43 Rabbit anti-Rat Polyclonal (PE) Antibody
Chicken, Bovine, Mouse, Rat, Human
ELISA, ICC, IHC, IP, WB
PE Conjugated
100 µl/$1,109
Select
GAP43 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
GAP43 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$798
GAP43 Antibody - IHC-P: GAP43 antibody testing of rat brain tissue
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GAP43 Rabbit anti-Human Polyclonal (aa216-238) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
GAP43 Protein - Recombinant Growth Associated Protein 43 By SDS-PAGE
Select
E. coli
His-T7
26.6 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
Viewing 1-25 of 123 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).