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GALR2 / Galanin Receptor 2
galanin receptor 2
Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.
| Gene Name: | galanin receptor 2 |
| Family/Subfamily: | GPCR , Galanin |
| Synonyms: | GALR2, Galanin-2 receptor, Gal-2 receptor, Galanin receptor type 2, GALNR2, GALR-2, Gal receptor 2, GAL subtype 2 receptor, Gal-r2, Galanin r2 receptor, GAL2-R, Galanin receptor 2, Galanin receptor subtype 2 |
| Target Sequences: | NM_003857 NP_003848.1 O43603 |
Publications (3)
1
Neuropeptides Profile and Increased Innervation in Becker's Nevus. Ji Seok Kim, Myeong Jin Park, Hye Young Kang, Seung Phil Hong, Byung Cheol Park, Myung Hwa Kim. Annals of dermatology. 2019 Apr;;31:154-163. [Full Text Article]
[PubMed:33911564]
[PMC:PMC7992669]
Related Antibodies: LS-B4081.
2
Activation of Galanin Receptor 1 with M617 Attenuates Neuronal Apoptosis via ERK/GSK-3ß/TIP60 Pathway After Subarachnoid Hemorrhage in Rats. Hui Shi, Yuanjian Fang, Lei Huang, Ling Gao, Cameron Lenahan, Takeshi Okada, Zachary D Travis, Shucai Xie, Hong Tang, Qin Lu, Rui Liu, Jiping Tang, Yuan Cheng, John H Zhang. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2021 July;18:1905-1921. [Full Text Article]
[PubMed:34086200]
[PMC:PMC8609084]
Related Antibodies: LS-C805729.
3
Galanin receptor 3 - A new pharmacological target in retina degeneration. Joseph T Ortega, Tanu Parmar, Beata Jastrzebska. Pharmacological research. 2023 February;188:106675. [Full Text Article]
[PubMed:36693600]
[PMC:PMC9918719]
Related Antibodies: LS-C805729.
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Antibodies
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(18)
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GALR2 / Galanin Receptor 2
(18)
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(18)
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(6)
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(14)
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(18)
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Publications
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(16)
Yes
(2)
GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
Neuroscience
Fast Shipping
GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal (Transmembrane Domain) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Neuroscience
Fast Shipping
GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal (aa201-250) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal (aa243-336) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$450
GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal (180-260 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal (aa189-238) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
GALR2 / Galanin Receptor 2 Goat anti-Human Polyclonal (aa128-141) Antibody
Chicken, Bovine, Mouse, Dog, Rat, Hamster, Horse, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$469
GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$469
GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$469
GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$321
GALR2 / Galanin Receptor 2 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Bovine, Human
WB
Unconjugated
100 µl/$299
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