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6737 Mowry Ave
Newark, CA 94560
United States
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GADD45A / GADD45
growth arrest and DNA-damage-inducible, alpha
GADD45A / GADD45 is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
| Gene Name: | growth arrest and DNA-damage-inducible, alpha |
| Synonyms: | GADD45A, DDIT-1, DDIT1, GADD45 |
| Target Sequences: | NM_001924 NP_001915.1 P24522 |
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