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GABRA4
gamma-aminobutyric acid (GABA) A receptor, alpha 4
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABA-A receptor subtype. GABA-A receptors are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A receptor is a multimeric subunit complex. To date six alpha, four beta, and four gamma subunits, plus alternative splicing variants of some of these subunits, have been identified. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor.
| Gene Name: | gamma-aminobutyric acid (GABA) A receptor, alpha 4 |
| Family/Subfamily: | Ion Channel , GABA A receptor |
| Synonyms: | GABRA4, GABA A receptor alpha 4, GABA(A) receptor, alpha 4 |
| Target Sequences: | NM_000809 NP_000800.2 P48169 |
Publications (2)
1
GABAA receptors are expressed and facilitate relaxation in airway smooth muscle. Mizuta K, Xu D, Pan Y, Comas G, Sonett JR, Zhang Y, Panettieri RA, Yang J, Emala CW. American journal of physiology. Lung cellular and molecular physiology. 2008 294:L1206-16. (WB; Guinea pig, Human)
[PubMed:18408071]
2
Novel Expression of GABAA Receptors on Resistance Arteries That Modulate Myogenic Tone. Peter D Yim, George Gallos, Steven A Lee-Kong, William Dan, Amy D Wu, Dingbang Xu, Dan E Berkowitz, Charles W Emala. Journal of vascular Research. 2020 February;57:113-125. [Full Text Article]
[PubMed:32097943]
[PMC:PMC7228859]
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Antibodies
(44)
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(44)
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GABRA4
(44)
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(44)
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(19)
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(42)
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(14)
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rabbit
(35)
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(26)
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(8)
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monoclonal mc
(8)
polyclonal pc
(36)
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(2)
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(1)
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(1)
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(21)
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(7)
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50-130 aa, Internal
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aa123-168
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(1)
aa64-113
(1)
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(1)
Publications
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(44)
Neuroscience
GABRA4 Goat anti-Human Polyclonal (aa349-361) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
GABRA4 Rabbit anti-Human Polyclonal (aa350-377) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
GABRA4 Rabbit anti-Human Polyclonal (aa36-258) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
GABRA4 Rabbit anti-Human Polyclonal (aa36-258) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
GABRA4 Rabbit anti-Human Polyclonal (aa36-258) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
GABRA4 Rabbit anti-Human Polyclonal (aa36-258) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
GABRA4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$321
GABRA4 Rabbit anti-Human Polyclonal (aa350-377) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
GABRA4 Rabbit anti-Human Polyclonal (aa350-377) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
GABRA4 Rabbit anti-Human Polyclonal (aa350-377) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
GABRA4 Rabbit anti-Human Polyclonal (aa350-377) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
GABRA4 Rabbit anti-Human Polyclonal (aa350-377) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
GABRA4 Rabbit anti-Human Polyclonal (aa350-377) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
GABRA4 Mouse anti-Human Monoclonal (S398A-34) Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
100 µg/$442
GABRA4 Mouse anti-Human Monoclonal (Biotin) (S398A-34) Antibody
Mouse, Rat, Human
IF, IHC, WB
Biotin Conjugated
100 µg/$475
GABRA4 Mouse anti-Human Monoclonal (FITC) (S398A-34) Antibody
Mouse, Rat, Human
IF, IHC, WB
FITC Conjugated
100 µg/$472
GABRA4 Mouse anti-Human Monoclonal (PerCP) (S398A-34) Antibody
Mouse, Rat, Human
IF, IHC, WB
PerCP Conjugated
100 µg/$478
GABRA4 Mouse anti-Human Monoclonal (APC) (S398A-34) Antibody
Mouse, Rat, Human
IF, IHC, WB
APC Conjugated
100 µg/$478
GABRA4 Mouse anti-Human Monoclonal (Atto 390) (S398A-34) Antibody
Mouse, Rat, Human
IF, IHC, WB
Atto 390 Conjugated
100 µg/$479
GABRA4 Mouse anti-Human Monoclonal (RPE) (S398A-34) Antibody
Mouse, Rat, Human
IF, IHC, WB
RPE Conjugated
100 µg/$477
GABRA4 Mouse anti-Human Monoclonal (Atto 594) (S398A-34) Antibody
Mouse, Rat, Human
IF, IHC, WB
Atto 594 Conjugated
100 µg/$479
GABRA4 Rabbit anti-Human Polyclonal (aa333-361) Antibody
Human
ELISA, Flo, WB
Unconjugated
200 µl/$734
GABRA4 Rabbit anti-Human Polyclonal (aa333-361) (PE) Antibody
Human
ELISA, Flo, WB
PE Conjugated
200 µl/$952
GABRA4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
GABRA4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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