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Newark, CA 94560
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GABPA / NRF2
GA binding protein transcription factor, alpha subunit 60kDa
GABPA / NRF2 is one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene.
| Gene Name: | GA binding protein transcription factor, alpha subunit 60kDa |
| Synonyms: | GABPA, E4TF1A, E4TF1-60, GA-binding protein alpha chain, NRF2A, RCH04A07, GABP subunit alpha, NFT2, NRF2, Transcription factor E4TF1-60 |
| Target Sequences: | NM_002040 NP_002031.2 Q06546 |
Publications (1)
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