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GABBR2 / GABA B Receptor 2

gamma-aminobutyric acid (GABA) B receptor, 2

Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.

Gene Name: gamma-aminobutyric acid (GABA) B receptor, 2
Family/Subfamily: GPCR , GABA(B)
Synonyms: GABBR2, G protein-coupled receptor 51, GABA(B2), GABA-B receptor 2, Gaba-b receptor r2, GABA-BR2, Gabab-receptor subunit 2, GABA(B)R2, GABA-B receptor, R2 subunit, GABA-B-R2, GABAB receptor-2, GPRC3B, Gb2, HRIHFB2099, G-protein coupled receptor 51, GPR51, HG20, GABA B Receptor 2, GABA-B2, GABAB2, GABABR2, Gbr2
Target Sequences: NM_005458 NP_005449.5 O75899

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Proteins (3)
Over-Expression Lysate (2)
Recombinant (1)
GABBR2 / GABA B Receptor 2 (3)
No (3)
GST (1)
Myc-DDK (Flag) (2)
Human (2)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (1)
GABBR2 / GABA B Receptor 2 Protein - 12.5% SDS-PAGE of human GABBR2 stained with Coomassie Blue
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Wheat Germ Extract
GST
126.3 kDa
10 µg/$479; 25 µg/$670
GABBR2 / GABA B Receptor 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
105.8 kDa
100 µg/$710
GABBR2 / GABA B Receptor 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
105.8 kDa
20 µg/$215
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).