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GAB3 is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants.
Gene Name: | GRB2-associated binding protein 3 |
Synonyms: | GAB3, DOS/Gab family member 3, Gab3 scaffolding protein, GRB2-associated binder 3 |
Target Sequences: | Q8WWW8 Q8WWW8 |
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