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Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.
Gene Name: | GRB2-associated binding protein 2 |
Synonyms: | GAB2, GRB2-associated binder 2, KIAA0571, Pp100 |
Target Sequences: | NM_012296 NP_036428.1 Q9UQC2 |
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