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FXYD1 / Phospholemman

FXYD domain containing ion transport regulator 1

FXYD1 / Phospholemman is a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature.

Gene Name: FXYD domain containing ion transport regulator 1
Family/Subfamily: Ion Channel Regulator , not assigned-Ion Channel Regulator
Synonyms: FXYD1, PLM, Phospholemman, Phospholemman chloride channel
Target Sequences: NM_005031 NP_005022.2 O00168

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Proteins (5)
Over-Expression Lysate (4)
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FXYD1 / Phospholemman (5)
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Myc-DDK (Flag) (5)
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293T Cells (2)
HEK 293 Cells (3)
FXYD1 / Phospholemman Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
8.3 kDa
20 µg/$150
FXYD1 / Phospholemman Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
10.44 kDa
20 µg/$150
FXYD1 / Phospholemman Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
8.3 kDa
100 µg/$494
FXYD1 / Phospholemman Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
10.44 kDa
100 µg/$494
FXYD1 / Phospholemman Protein - Purified recombinant protein FXYD1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
8.3 kDa
20 µg/$1,107
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).