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FXN / Frataxin

frataxin

Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+; the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1.

Gene Name: frataxin
Synonyms: FXN, CyaY, Frataxin, mitochondrial, Friedreich ataxia protein, FARR, Friedreich ataxia, FA, FRDA, X25, Frataxin
Target Sequences: NM_000144 NP_000135.2 Q16595

Publications (3)

1
Characterization of a new N-terminally acetylated extra-mitochondrial isoform of frataxin in human erythrocytes. Guo L, Wang Q, Weng L, Hauser LA, Strawser CJ, Mesaros C, Lynch DR, Blair IA. Scientific reports. 2018 November;8:17043. [Full Text Article] [PubMed:30451920] [PMC:PMC6242848] Related Antibodies: LS-C197243.
2
Liquid Chromatography-High Resolution Mass Spectrometry Analysis of Platelet Frataxin as a Protein Biomarker for the Rare Disease Friedreich's Ataxia. Lili Guo, Qingqing Wang, Liwei Weng, Lauren A Hauser, Cassandra J Strawser, Agostinho G Rocha, Andrew Dancis, Clementina Mesaros, David R Lynch, Ian A Blair. Analytical Chemistry. 2018 February;90:2216-2223. [Full Text Article] [PubMed:29272104] [PMC:PMC5817373] Related Antibodies: LS-C197243.
3
Evaluation of antibodies for western blot analysis of frataxin protein isoforms. Liwei Weng, Qingqing Wang, Sixiang Yu, Xiaolu Yang, David R Lynch, Clementina Mesaros, Ian A Blair. Journal of immunological methods. 2019 Nov;474:112629. [Full Text Article] [PubMed:31279523] [PMC:PMC6829029] Related Antibodies: LS-C197243.

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Products
Antibodies (93)
Primary (93)
FXN / Frataxin (93)
Human (81)
Mouse (30)
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FXN / Frataxin Antibody - Anti-FXN / Frataxin antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FXN / Frataxin Rabbit anti-Rat Polyclonal (aa105-154) Antibody
Rat
IHC, IHC-P, WB
Unconjugated
50 µl/$460
FXN / Frataxin Antibody - Anti-FXN / Frataxin antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FXN / Frataxin Rabbit anti-Rat Polyclonal (aa105-154) (HRP) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
FXN / Frataxin Antibody - Anti-FXN / Frataxin antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FXN / Frataxin Rabbit anti-Rat Polyclonal (aa105-154) (Biotin) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Human, Monkey
IHC, WB
Biotin Conjugated
100 µl/$469
FXN / Frataxin Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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FXN / Frataxin Rabbit anti-Human Polyclonal (aa57-198) Antibody
Human
ICC, IHC-P, WB
Unconjugated
50 µl/$460
FXN / Frataxin Antibody - Immunoprecipitation of FXN transfected lysate using anti-FXN monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with FXN rabbit polyclonal antibody.
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FXN / Frataxin Mouse anti-Human Monoclonal (1D9) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$423
FXN / Frataxin Antibody - ICC/IF analysis of Frataxin in A549 cell line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human Frataxin antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green).
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FXN / Frataxin Mouse anti-Human Monoclonal (AT10E11) Antibody
Human
ELISA, Flo, ICC, WB
Unconjugated
50 µl/$303; 100 µl/$365
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FXN / Frataxin Rabbit anti-Human Polyclonal (aa143-172) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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FXN / Frataxin Rabbit anti-Human Polyclonal (aa143-172) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
FXN / Frataxin Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-FXN mouse monoclonal antibody.
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FXN / Frataxin Mouse anti-Human Monoclonal (OTI1C12) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
FXN / Frataxin Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-FXN mouse monoclonal antibody.
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FXN / Frataxin Mouse anti-Human Monoclonal (Carrier-free) (OTI1C12) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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FXN / Frataxin Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µg/$513; 100 µg/$832
FXN / Frataxin Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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FXN / Frataxin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
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FXN / Frataxin Rabbit anti-Human Polyclonal (aa72-102) (Azide-free) (HRP) Antibody
Human
ELISA, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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FXN / Frataxin Rabbit anti-Human Polyclonal (aa72-102) (APC) Antibody
Human
ELISA, IF, IHC, WB
APC Conjugated
200 µl/$952
FXN / Frataxin Antibody - Immunohistochemistry of paraffin-embedded human liver cancer using FXN antibody at dilution of 1:100 (200x lens).
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FXN / Frataxin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
FXN / Frataxin Antibody - Anti-FXN mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY FXN.
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FXN / Frataxin Mouse anti-Human Monoclonal (OTI4G4) Antibody
Human
IF, WB
Unconjugated
100 µl/$434
FXN / Frataxin Antibody - Anti-FXN mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY FXN.
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FXN / Frataxin Mouse anti-Human Monoclonal (OTI3C3) Antibody
Human
IF, WB
Unconjugated
100 µl/$434
FXN / Frataxin Antibody - Anti-FXN mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY FXN.
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FXN / Frataxin Mouse anti-Human Monoclonal (OTI3B6) Antibody
Human
IF, WB
Unconjugated
100 µl/$434
FXN / Frataxin Antibody - 1:100 staining mouse testis tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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FXN / Frataxin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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FXN / Frataxin Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
ELISA, WB
Unconjugated
100 µl/$801
FXN / Frataxin Antibody - Western blot All lanes: FXN antibody at 2µg/ml Lane 1: HepG2 whole cell lysate Lane 2: Hela whole cell lysate Lane 3: Mouse brain tissue Lane4: Jurkat whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 23 kDa Observed band size: 23 kDa
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FXN / Frataxin Rabbit anti-Mouse Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
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FXN / Frataxin Rabbit anti-Mouse Polyclonal (HRP) Antibody
Mouse, Human
ELISA, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
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FXN / Frataxin Rabbit anti-Mouse Polyclonal (Biotin) Antibody
Mouse, Human
ELISA, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
FXN / Frataxin Antibody - FXN / Frataxin antibody Western blot of Mouse Heart lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FXN / Frataxin Rabbit anti-Mouse Polyclonal (aa80-129) (Biotin) Antibody
Rabbit, Mouse, Bovine, Horse, Gibbon, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
FXN / Frataxin Antibody - Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with FXN antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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FXN / Frataxin Rabbit anti-Human Polyclonal (aa72-102) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).